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Professor

Ph.D. - University College of North Wales, 1971

Phone: 301-405-1380
Email: imather@umd.edu

Representative Publications:

Jack, L.J.W., and Mather, I.H.  1990.  Cloning and analysis of cDNA encoding bovine butyrophilin, an apical glycoprotein expressed in mammary tissue and secreted in association with the milk-fat-globule membrane during lactation, J. Biol. Chem., 265:14481-14486.

Vernet, C., Boretto, J., Mattei, M.-G., Takahashi, M., Jack, L.J.W., Mather, I.H., Rouquier, S., and Pontarotti, P.  1993. Evolutionary study of multigenic families mapping close to the human MHC class I region, J. Mol. Evol., 37:600-612.

Banghart, L.R., Chamberlain, C.W., Velarde, J., Korobko, I.V., Ogg, S.L., Jack, L.J.W.,  Vakharia, V.N., and Mather, I.H.  1998.  Butyrophilin is expressed in mammary epithelial cells from a single-sized messenger RNA as a type I membrane glycoprotein, J. Biol. Chem., 273: 4171-4179.

Mather, I.H., and Keenan, T.W.  1998.  Origin and secretion of milk lipids, J. Mam. Gland Biol. Neoplasia, 3, 259-273.

Stefferl, A., Schubart, A., Storch, M., Amini, A., Mather, I.H., Lassmann, H., and Linington, C. 2000. Butyrophilin, a milk protein, modulates the encephalitogenic T cell response to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis, J. Immunol., 165:2859-2865.

Ogg, S.L., Weldon, A.K., Dobbie L., Smith, A.J.H., and Mather, I.H. 2004 Expression of Butyrophilin (Btn1a1) in lactating mammary gland is essential for the regulated secretion of milk-lipid droplets, Proc. Natl. Acad. Sci. (U.S.A.), 101:10084-10089.

Baumann, D.E., Mather, I.H., Wall, R.J., and Lock, A.L. 2006 Major advances associated with the biosynthesis of milk, J. Dairy Sci. (Centennial edition), 89: 1235-1243.