Profile | Teaching | Research | Publications | Grants | Website | Faculty Directory

Assistant Professor

Ph.D. - State University of New York at Buffalo School of Medicine, 1998

Phone: 301-405-0649
Email: hamza@umd.edu

Representative Publications:

Hamza I, Prohaska JR, and Gitlin. JD. Essential Role for Atox1 in the Copper-Mediated Intracellular Trafficking of the Menkes ATPase. Proc Natl Acad Sci. 2003; 100:1215-1220

Hamza I and Gitlin JD. Copper chaperones for cytochrome c oxidase and human disease. J Bioenerg Biomembr. 2002; 34:381-388

Hamza I, Faisst A, Prohaska JR, Chen J, Gruss P and Gitlin. JD. The metallochaperone Atox1 plays a critical role in perinatal copper homeostasis. Proc Natl Acad Sci. 2001; 98: 6848-6852 (Editorial)

Hamza I, Schaefer M, Klomp LWJ and Gitlin JD. Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis. Proc Natl Acad Sci. 1999; 96:13363-13368.

Hamza I, Chauhan S, Hassett R, and O’Brian MR. The bacterial Irr protein is required for coordination of heme biosynthesis with iron availability. J Biol Chem. 1998; 273:21669-21674.

 

Figure depicts that organismic and cellular copper homeostasis have to be maintained due to the bi-modal nature of copper, both, as a critical cofactor for normal growth and development and in disease pathophysiology.